Appreciate the replies. At least I know I'm not the only one having this problem. I also did the manual pairing and Im not convinced thats a complete fix because Im still having the power off issue.
Are you re-pairing the remote to the box, or going into the menu and choosing the TV make and model of your TV for the remote to operate? Also you do have to point the remote at the TV, the Fios one box works with bluetooth,, so you don't have to point it there. Go to Menu > Settings > Voice Control > Fios TV Voice Remote > Program Voice Remote > Manual Setup > Press ‘OK’ to select. Choose your TV > Press OK.